Expression Pattern of Glucose Transporter GLUT1 Protein
نویسندگان
چکیده
منابع مشابه
GLUT1 deficiency and other glucose transporter diseases.
We review the three genetically determined disorders of glucose transport across cell membranes. Diseases such as glucose-galactose malabsorption, Fanconi-Bickel syndrome and De Vivo disease (GLUT1 deficiency syndrome (GLUT1DS)) arise from heritable mutations in transporter-encoding genes that impair monosaccharide uptake, which becomes rate-limiting in tissues where the transporters serve as t...
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Glucose transport is a highly regulated process and is dependent on a variety of signaling events. Glycogen synthase kinase-3 (GSK-3) has been implicated in various aspects of the regulation of glucose transport, but the mechanisms by which GSK-3 activity affects glucose uptake have not been well defined. We report that basal glycogen synthase kinase-3 (GSK-3) activity regulates glucose transpo...
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3T3-L1 preadipocytes ectopically expressing the mammalian RNA-binding protein Hel-N1 expressed up to 10-fold more glucose transporter (GLUT1) protein and exhibited elevated rates of basal glucose uptake. Hel-N1 is a member of the ELAV-like family of proteins associated with the induction and maintenance of differentiation in various species. ELAV proteins are known to bind in vitro to short str...
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Glucose transporters (GLUTs) provide a pathway for glucose transport across membranes. Human GLUTs are implicated in devastating diseases such as heart disease, hyper- and hypo-glycemia, type 2 diabetes and cancer. The human GLUT1 has been recently crystalized in the inward-facing open conformation. However, there is no other structural information for other conformations. The X-ray structures ...
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814 Regulation of the glucose transporter GLUT I in mammalian cells Stephen A. Baldwin*ll, On Kan*t, Anthony D. Whettont, Sally Martin$T, Hilary A. C. Fawcett*$, David J. Flint+ and Colin J. Wildet *Department of Biochemistry and Molecular Biology, University of Leeds, Leeds LS2 9JT, U.K., tDepartment of Biochemistry and Applied Molecular Biology, University of Manchester Institute of Science a...
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ژورنال
عنوان ژورنال: Journal of Korean Breast Cancer Society
سال: 2001
ISSN: 1598-3641
DOI: 10.4048/jkbcs.2001.4.2.161